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Combining it with blood thinners significantly raises the risk of internal bleeding

NPAS4 is a neuroprotective protein and acts as a TF, regulating the transcription of a diverse set of genes involved in synaptic plasticity, neurotransmission, and neuronal survival 58

Thus, although some of the damage in this experimental model of colitis reflects a direct erosive effect of TNBS and ethanol, their combined administration to rats reflects the in vivo operation of the damaging mechanisms elicited by TNBS, namely GSH depletion and ROS generation, indicating that ethanol facilitates the access of TNBS to the cell interior ensuring TNBS-induced GSH depletion and ROS generation

MIT Press